问题描述：
[单选]
在局部用药的情况下，以下哪个步骤是达到血浆治疗药物浓度的最关键的？In case of tropical use of drug administration which of the following steps is most critical to achieve a therapeutic drug concentration in plasma？
A．吸收Absorption
B．分布Distribution
C．排泄Elimination
D．糖基化Glycosylation
E．代谢Metabolism
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